Dr Letterman, the diabolical mad genius, has vanished from the Institute for Really Dangerous Studies and reappeared to hold the world for ransom. He's been traced to the tiny Polynesian island of Puyo Puyo. As Agent Orange, it's up to you to stop him at all costs.
Notes
This was an entry in Speed-IF 10^-9. Contrary to the title, Bob Hope does not feature, but H G Wells does.